Evaluation of a new TyG indicator, TyHGB, in predicting non-alcoholic fatty liver disease: evidence from two independent populations.

ABSTRACT:

Background

As non-alcoholic fatty liver disease (NAFLD) becomes increasingly common and affects population health, simple and effective screening tools for NAFLD are essential. The triglyceride high-density cholesterol-glucose body index (TyHGB), a novel metabolic index, has shown promise for predicting metabolic disorders. The objective of this research was to assess TyHGB's predictive capability for NAFLD across two distinct cohorts.

Methods

This retrospective study utilized data obtained from two independent cohorts: a Chinese hospital cohort (n = 181,241) and the National Health and Nutrition Examination Survey (NHANES) cohort (n = 3,286). TyHGB was computed according to the following equation: triglyceride level/high-density lipoprotein cholesterol level + 0.7 × fasting

SUBMITTER: Zhao E 

PROVIDER: S-EPMC12551267 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature