Cognitive dysfunction in schizophrenia: association with peripheral blood inflammatory signatures.

ABSTRACT:

Background

Schizophrenia (SCZ) is a complex, chronic neuropsychiatric disorder involving genetic, neurotransmitter, and immune system interactions. The immune-inflammatory hypothesis has emerged as a key research focus, with evidence suggesting that aberrant peripheral inflammatory factors may cross the blood-brain barrier, contributing to neurodegeneration and cognitive impairment. However, most studies have focused on single or a few inflammatory factors, with heterogeneous results, and their clinical utility as biomarkers remains unclear. This study aims to identify differentially expressed inflammatory factors in the peripheral blood of SCZ patients undergoing olanzapine treatment, evaluate their diagnostic efficacy using multidimensional statistical modeling, and investigate c

SUBMITTER: Luan P 

PROVIDER: S-EPMC12551270 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature