ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer.

ABSTRACT:

Background

The Rho GTPase-activating protein (RhoGAP) family represents a large and diverse group of proteins that act as key regulators of Rho GTPases, small GTP-binding proteins involved in cellular signaling. Tight regulation of Rho GTPase activity is essential for fundamental biological processes, including cell motility, contractility, growth, differentiation, and development. Despite their biological importance, the roles of RhoGAPs in cancer remain largely undefined.

Methods

Bioinformatics analysis was performed using data from The Cancer Genome Atlas (TCGA), covering over 10,000 samples across 33 cancer types. The role of ARHGAP11A in the DNA damage response was evaluated through single-cell sequencing, western blotting, and colony formation assays.

Results

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SUBMITTER: Tan K 

PROVIDER: S-EPMC12551307 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature