Monocyte-to-HDL ratio (MHR) as a novel biomarker: reference ranges and associations with inflammatory diseases and disease-specific mortality.

ABSTRACT:

Background

Monocyte-to-HDL Ratio (MHR) biomarker reflects monocyte-driven inflammation and HDL's anti-inflammatory properties. MHR's reference ranges and prognostic utility remain undefined. We establish normal MHR reference ranges and examine its association with inflammatory diseases and mortality.

Methods

Using NHANES data (1999-2018, 2021-2023), two sets of sex-specific MHR reference ranges were generated using two healthy adult populations (monocyte count: 6,757; monocyte percentage: 6,817). Further analyses utilized MHR by monocyte count for more straightforward interpretation. Adjusted associations between MHR and inflammatory diseases were assessed in 49,929 adults, and disease-specific mortality in 35,781.

Results

The 2.5th-97.5th percentiles for MHR by monoc

SUBMITTER: Arabi A 

PROVIDER: S-EPMC12551338 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature