A Proteomic Discovery Study of Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage.

ABSTRACT:

Background

Proteomic analysis of cerebrospinal fluid (CSF) has the potential to provide insight into the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) and target trials to improve outcome. The aim of this study was to perform a definitive proteomic analysis of CSF following aSAH to identify proteins associated with neurological injury.

Methods

This was a retrospective proteomic analysis of CSF collected at neurosurgical centers in the United Kingdom between 2013 and 2023 either from external ventricular drain or lumbar puncture on day 7 after aSAH. Adults with confirmed aSAH were included. Exclusions were pregnancy, severe comorbidities, inability to follow-up, and those not expected to survive 24 hours. Proteomic analysis was performed using mass spectrometry

SUBMITTER: Gaastra B 

PROVIDER: S-EPMC12551419 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature