BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy.

ABSTRACT:

Background

Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels of depression. This observational study investigates blood oxygenation level-dependent LRTC changes alongside therapy-induced language and mood improvements in perisylvian and domain-general brain areas.

Methods

Sixteen patients with chronic poststroke aphasia underwent functional magnetic resonance imaging before and after 2 to 4 weeks of intensive language-action therapy. Therapy took place at Freie Universität Berlin (2014

SUBMITTER: Jager AP 

PROVIDER: S-EPMC12551423 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature