No difference in microbial diversity between bronchoalveolar lavage and tracheal sampling: a systematic review and meta-analysis.

ABSTRACT:

Introduction

The respiratory microbiome has a vital role in maintaining respiratory health and preventing pathogen colonisation, but traditional diagnostic methods fail to capture a complete picture of it. Metagenomic sequencing has improved our understanding of microbial ecosystems in both acute and chronic pathologies. However, its results have not been systematically compared between different respiratory sampling techniques, as has been done with traditional methods. Our study aims to compare the microbial diversity in bronchoalveolar lavage (BAL) and tracheal samples using microbiome sequencing.

Methods

A systematic search was conducted in Medline, Embase and CENTRAL databases to identify studies where lower respiratory tract microbiome specimens were collected simultan

SUBMITTER: Karim DM 

PROVIDER: S-EPMC12551526 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature