Early structural brain abnormalities in borderline personality disorder.

ABSTRACT:

Background

Structural imaging studies of borderline personality disorder (BPD) have identified regions of reduced and increased cortical volume, as well as volume reductions in the hippocampus and amygdala, although with considerable variability across studies. Examining adolescent patients with the disorder can reduce potential confounding effects such as later development of affective and other comorbid disorders.

Methods

Fifty-one adolescents (48 females, 3 males) with BPD and without comorbid disorders and with 43 matched healthy controls underwent whole-brain voxel-based morphometry (VBM). Hippocampus and amygdala volumes were also measured using conventional volumetric techniques.

Results

At a threshold of p = 0.05 corrected, the BPD patients exhibited a

SUBMITTER: Salgado-Pineda P 

PROVIDER: S-EPMC12551577 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature