Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression.

ABSTRACT:

Background

Late-onset depression (LOD) is featured by disrupted cognitive performance, which is refractory to conventional treatments and increases the risk of dementia. Aberrant functional connectivity among various brain regions has been reported in LOD, but their abnormal patterns of functional network connectivity remain unclear in LOD.

Methods

A total of 82 LOD and 101 healthy older adults (HOA) accepted functional magnetic resonance imaging scanning and a battery of neuropsychological tests. Static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) were analyzed using independent component analysis, with dFNC assessed via a sliding window approach. Both sFNC and dFNC contributions were classified using a support vector machine.

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC12551583 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature