Steroid Withdrawal Versus Maintenance in Simultaneous Pancreas-Kidney Transplantation: Long-Term Outcomes in a Single-Center Retrospective Cohort.

ABSTRACT:

Background

Simultaneous pancreas and kidney (SPK) transplants using steroid-free regimens are a frequently used immunosuppressive strategy in low immunologic risk recipients. The long-term effect on recipient outcomes remains incompletely understood.

Methods

We analyzed post-transplant outcomes in 307 SPK recipients from a single center, comparing early steroid withdrawal (after completion of Thymoglobulin) with maintenance steroids. Steroid withdrawal was primarily utilized in low immunologic risk patients.

Results

In total, 170 SPK recipients underwent steroid withdrawal, and 137 received maintenance steroids. The withdrawal group had a lower cPRA and included fewer Black recipients. Biopsy-proven rejection rates (kidney, pancreas, or both) were similar between grou

SUBMITTER: Meier RPH 

PROVIDER: S-EPMC12551689 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature