Metabolic regulation of behavior by the intestinal enzyme FMO-2.

ABSTRACT: Many elements of an organism's behavior are intertwined with the organism's health. Over a long period of time, health status is also indicative of life span, with improved health correlating with a longer life. However, the relationship between longevity and behavior remains relatively unexplored. Here, we report that modification of a single longevity gene downstream of dietary restriction and hypoxia markedly alters behavior in Caenorhabditis elegans. We found that modified expression of flavin-containing monooxygenase (fmo-2) leads to altered sensory perception and decision-making in a variety of behavioral paradigms. This cell nonautonomous signaling pathway is linked to changes in tryptophan metabolism, where loss of fmo-2 requires the tryptophan metabolite serot

SUBMITTER: Kitto ES 

PROVIDER: S-EPMC12551704 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature