Infections in primary sclerosing cholangitis and inflammatory bowel disease: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that frequently coexists with inflammatory bowel disease (IBD). The risk of infections in patients with concurrent PSC-IBD remains unclear. The aim of this study was to identify the event rate of infections and associated risk factors in PSC-IBD patients.

Methods

MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception to September 12, 2024 for studies examining event rate or risk factors for infection in patients with PSC-IBD. The primary outcome was the event rate of all-cause and site-specific infections as well as infection-related mortality. The secondary outcome was risk factors for infection. Random-effects models were used to calculate pooled odds r

SUBMITTER: Natt N 

PROVIDER: S-EPMC12551746 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature