The pursuit of novel head and neck cancer biomarkers - tissue and blood expression of chloride intracellular channels family.

ABSTRACT:

Introduction

The chloride intracellular channels (CLICs) engage in cancer pathogenesis and have been considered various cancer biomarkers and therapeutic targets. Preliminary research suggests CLICs may be important players in head and neck squamous cell carcinoma (HNSCC). There is a need for reliable HNSCC biomarkers besides well-known HPV and PD-L1.

Aim

The study aimed to assess the role of CLICs in HNSCC pathogenesis and as potential disease biomarkers.

Methods

We compared the CLIC1-CLIC6 genes expression between the HNSCC tumors (n = 99) and the tissue from the free surgical margin (n = 74) at the mRNA level with RT-qPCR and at the protein level with Western Blot. To investigate the role of CLIC1-CLIC6 proteins as potential HNSCC blood biomarkers, we performed the

SUBMITTER: Wojtera BP 

PROVIDER: S-EPMC12551828 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature