A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets.

ABSTRACT: Porcine deltacoronavirus (PDCoV), an enteric member of the coronavirus family, has emerged globally over the past decade, causing significant impacts on the swine industry. While studies of virus-host protein interactions provide crucial insights into viral engagement with host cells during infection, research specifically targeting PDCoV-host interaction factors remains limited. To identify host proteins involved in PDCoV replication, comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) was employed to identify host proteins interacting with the PDCoV genomic RNA. Concurrently, affinity purification mass spectrometry (AP-MS) was utilized to identify host interactors of PDCoV-encoded proteins. A total of 671 host proteins were identified in our analysis. The

SUBMITTER: Yan W 

PROVIDER: S-EPMC12551863 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature