Quantitative Ultrasound-Based Characterization of Placental Tissue Microstructure in a Rat Model of Preeclampsia.

ABSTRACT:

Objective

Quantitative ultrasound (QUS) methods were applied to detect changes in placental microstructure in the reduced uterine perfusion pressure (RUPP) model of preeclampsia in rats. Preeclampsia is a life-threatening pregnancy disorder associated with abnormal placental development that is inadequately treated and managed.

Methods

Nine timed-pregnant Sprague-Dawley rats were used in this study. On gestational day 14 (GD 14), five rats received RUPP surgery to induce preeclampsia. US radiofrequency data were acquired for QUS analysis on GD18. On GD19, animals were sacrificed and dissected to acquire placental tissue samples. The cell nuclear diameter in each anatomical layer of the placenta was measured to compare with regional effective scatterer diameter (ESD) values.<

SUBMITTER: Markel AC 

PROVIDER: S-EPMC12551963 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature