Impact of Exendin-4 on the Differentiation and Function of Transplanted Porcine Neonatal Pancreatic Cell Clusters in Diabetic Nude Mice.

ABSTRACT: Porcine neonatal pancreatic cell clusters (NPCCs) are a promising and abundant source for islet transplantation owing to their ability to secrete insulin and proliferative potential. However, a significant limitation is the delayed normalization of blood glucose following transplantation, largely attributed to incomplete β-cell differentiation. Exendin-4, a glucagon-like peptide-1 receptor agonist, has been shown to enhance β-cell differentiation, proliferation, and function in various models. This study was aimed at investigating whether posttransplant treatment with exendin-4 could accelerate NPCC differentiation and improve long-term glycemic outcomes in diabetic nude mice. NPCCs were isolated from 1- to 3-day-old piglets and transplanted under the kidney capsule of strept

SUBMITTER: Juang JH 

PROVIDER: S-EPMC12552079 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature