High Prevalence of <i>Plasmodium falciparum</i> HRP2/3 Gene Deletions in Ethiopia: Implications for Malaria Diagnosis and Treatment-A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Plasmodium parasite species are the causative agents of malaria, which affects populations worldwide. Rapid diagnostic tests (RDTs), microscopy, and molecular methods have been used to diagnose the disease. HRP2 antigens are unique to P. falciparum, while RDTs can detect lactate dehydrogenase, aldolase, and HRP3. Nevertheless, PfHRP2-based RDTs may produce false-negative results if the parasite's PfHRP2/3 genes are deleted. This study is necessary because there is currently no compiled evidence-based information regarding PfHRP2/3 gene deletion in Ethiopia.

Methods

Primary research articles on PfHRP2/3 gene deletions (2000-2025) were retrieved from PubMed, Science Direct, and Google Scholar. Eligible studies were systematically searched between May

SUBMITTER: Gebrie H 

PROVIDER: S-EPMC12552085 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature