Antifungal activity of ETD151 against azole-susceptible and -resistant <i>Aspergillus fumigatus</i> clinical isolates.

ABSTRACT: Aspergillus fumigatus is an opportunistic pathogen responsible for a wide spectrum of severe diseases, depending on the host's immune status. Current therapeutic options against this fungus are limited, and the emergence of resistance against azole derivatives, which are the first-line therapy, regardless of the clinical form, poses serious clinical challenges. Antimicrobial peptides, now used routinely, are valuable alternatives to conventional antibiotics for treating certain bacterial infections. In this study, we investigated the antifungal potential of ETD151, a synthetic peptide, against A. fumigatus clinical strains. Using cell-free in vitro assays and primary human bronchial epithelial cell (PHBEC) infection models, we demonstrated that ETD151 significantly reduces A.

SUBMITTER: Rochard C 

PROVIDER: S-EPMC12552151 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature