Retrospective cohort study on the correlation between serum 25(OH)D, vitamin A and neonatal respiratory distress syndrome (NRDS) in premature infants.

ABSTRACT:

Background

Premature infants are at high risk for neonatal respiratory distress syndrome (NRDS) due to underdeveloped lungs. Understanding serum 25-hydroxyvitamin D [25(OH)D] and vitamin A's roles may improve early intervention strategies. This study explores the correlation between NRDS and serum 25(OH)D and vitamin A levels in premature infants.

Methods

A retrospective cohort study was conducted involving 148 premature infants. The characteristics of infants diagnosed with NRDS were compared to those without NRDS. Statistical analyses included logistic regression to evaluate the interaction between serum 25(OH)D and vitamin A levels.

Results

Premature infants with NRDS exhibited significantly lower levels of both 25(OH)D and vitamin A compared to those without NRDS.

SUBMITTER: Yu J 

PROVIDER: S-EPMC12552159 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature