Advances in the research on circular RNA in pediatric pancreatic tumors.

ABSTRACT: Pancreatic cancer (PC), characterized by its insidious onset and extreme malignancy, is one of the most aggressive and lethal malignancies and poses significant challenges in clinical management, with a dismal 5-year survival rate due to late diagnosis and limited treatment options. Although advances have been made in understanding adult pancreatic tumors, pediatric pancreatic tumors (PPTs) remain understudied, with research on their molecular mechanisms and potential biomarkers still in the early stages. Circular RNAs (circRNAs), a newly discovered class of endogenous noncoding RNA molecules, have recently been identified as key regulators in tumorigenesis, progression, and therapeutic response. Unlike linear RNAs, circRNAs possess a unique covalently closed-loop structure, which confers

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12552170 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature