Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation.

ABSTRACT:

Background

Prenatal closure of the ductus arteriosus (DA) is an uncommon but potentially severe condition that can result in persistent pulmonary hypertension of the newborn (PPHN), right ventricular (RV) dysfunction, and even fetal demise. While often associated with maternal exposure to non-steroidal anti-inflammatory drugs (NSAIDs), idiopathic cases are also reported. The pathophysiology involves disruption of prostaglandin-mediated DA patency, leading to increased pulmonary vascular resistance (PVR) and RV afterload, with subsequent postnatal hemodynamic compromise. Given the rarity of this entity, management strategies are based primarily on case series and expert opinion.

Case description

We report two full-term newborns diagnosed with idiopathic prenatal closure of th

SUBMITTER: Mwizerwa L 

PROVIDER: S-EPMC12552187 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature