Clinical predictors of pseudoprogression in glioblastoma: a retrospective cohort analysis.

ABSTRACT:

Purpose

Distinguishing pseudoprogression (PsP) from true progression (TP) in glioblastoma (GBM) remains a diagnostic challenge, yet is essential for guiding treatment and counseling prognosis. This study retrospectively assessed the incidence, clinical predictors, and survival impact of PsP compared to TP.

Methods

Patients with surgically treated GBM and postoperative (chemo)radiotherapy in two Dutch hospitals (2006-2021) were included. Reports of magnetic resonance imaging (MRI) scans performed 4 months post-radiotherapy and at 3-month intervals, as well as reports of MRI scans prompted by neurological decline, were evaluated for PsP, TP, or mixed response (MR). Associations with clinical, tumor, and treatment characteristics and overall survival (OS) were analyzed.

Resu

SUBMITTER: Hoosemans LJN 

PROVIDER: S-EPMC12552241 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature