Subject-specific Functional ROIs Enhance Reliability in Language FMRI.

ABSTRACT:

Purpose

Functional MRI can be used to identify individual language-sensitive brain regions in the setting of presurgical diagnostics to improve functional postoperative outcome. In this study, a proven language task was adapted into German and tested with regard to its effectiveness, robustness and reliability in a time frame appropriate for the clinical setting. In addition, two different analysis approaches were compared to address the problem of arbitrary statistical thresholds commonly used in the clinical routine to derive contrast maps.

Methods

On two different days, 24 healthy volunteers were examined in a 3T MRI, whereby the task was run twice in each session. The fMRI included two conditions in a block design, reading of sentences and reading of pronounceable nonwor

SUBMITTER: Kube JMV 

PROVIDER: S-EPMC12552277 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature