Global burden of acute lymphoblastic leukemia following the COVID-19 pandemic.

ABSTRACT:

Objective

ALL is the most common childhood cancer globally, accounting for about 25% of cancer diagnoses in children under 15 years old. This study aimed to investigate the temporal trends and disparities in the global burden of ALL following the COVID-19 pandemic using data from the Global Burden of Disease (GBD) 2021 study.

Methods

Data were obtained from the GBD 2021 database, covering 204 countries and territories across five socio-demographic index (SDI) regions. Incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were analyzed, with age-standardized rates (ASRs) calculated for comparability. Joinpoint regression models and estimated annual percentage change (EAPC) were used to assess temporal trends from 1990 to 2021.

Results

Globally, t

SUBMITTER: Fan H 

PROVIDER: S-EPMC12552365 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature