Clinical significance on switching CDK4/6 inhibitors among 13,284 patients with metastatic breast cancer.

ABSTRACT: Recent clinical trials have shown that switching to a combination therapy of a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) and endocrine therapy (ET) prolongs progression-free survival (PFS) compared with ET monotherapy. Reports indicate that abemaciclib provides benefits regardless of the PIK3CA mutation status; however, its clinical benefits remain insufficient. This study aimed to evaluate the clinical significance of switching CDK4/6i + ET in a large real-world cohort. Using a medical database, we identified 13,284 patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer who received CDK4/6i + ET between 2008 and 2022. Patients were categorized into five groups based on their first- and second-line therapy patterns. We compare

SUBMITTER: Nishina T 

PROVIDER: S-EPMC12552409 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature