Relationship between cortical thickness and serotonin 1A receptor binding in bipolar disorder.

ABSTRACT: Deficits in cortical thickness have been a replicated finding in BD. Greater brain serotonin 1 A receptor (5HT1AR) binding has also been reported in BD, consistent with a disruption in serotonin signaling. Serotonin can cause a trophic effect on the cerebral cortex. 31 depressed participants with BD and 49 healthy volunteers (HVs) were included. PET imaging with [¹¹C]WAY100635 was obtained with a metabolite-corrected arterial input function. Radiotracer binding potential (BP_F) values were quantified within cortical regions. T1-weighted MRI scans were processed through Freesurfer 7.1.1, and cortical thickness values were quantified within a right caudal middle frontal region that had previously been shown to have deficits in BD. The previous results were replicated her

SUBMITTER: Lan MJ 

PROVIDER: S-EPMC12552417 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature