Medical comorbidities prognosticate survival in glioblastoma.

ABSTRACT:

Background

Medical comorbidities are prevalent in the glioblastoma population, although their effects on survival are not well established.

Methods

We retrospectively extracted known prognostic factors and medical comorbidities at the time of glioblastoma diagnosis for 867 patients who presented to Rhode Island Hospital from 2005-2022.

Results

All established prognostic factors were represented. Median age was 65 years (range <1-93). A higher number of comorbidities was associated with older age (p < 0.0001). Having >5 comorbidities doubled the hazard ratio compared to ≤1. While comorbidity burden correlated with decreased survival, the Charlson Comorbidity Index mainly captured the effect of age (Spearman r² = 0.874) while secondarily accounting for comorb

SUBMITTER: Bessette J 

PROVIDER: S-EPMC12552421 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature