ACTG1 driven splicing of P4HB gene enhances EMT and bladder cancer progression.

ABSTRACT: Bladder cancer (BLCA) remains a major health challenge due to its high incidence and poor prognosis. This study delves into the role of Actin Gamma 1 (ACTG1) in modulating the splicing of the P4HB gene, leading to the formation of the circular RNA circ_0046263, and its impact on epithelial-mesenchymal transition (EMT) and BLCA progression. Utilizing transcriptome and clinical data from The Cancer Genome Atlas (TCGA) and splicing data from the TCGA SpliceSeq database, we identified survival-associated splicing events through least absolute shrinkage and selection operator (LASSO) regression and Cox analysis. A meta-analysis of BLCA-related mRNA sequencing datasets from the gene expression omnibus (GEO) database validated the differential expression of ACTG1. Immune infiltration analysis and

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12552429 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature