Homeostasis of glucose and lipid metabolism during physiological responses to a simulated hypoxic high altitude environment.

ABSTRACT: Homeostasis facilitates maintenance of physiological processes despite extrinsic fluctuations. In aerobic organisms, homeostasis is mainly fueled by metabolism of glucose and lipids, and requires oxygen as a metabolic substrate. Lack of oxygen can therefore trigger an imbalance of homeostasis in vivo. How animals living at high altitude hypoxic conditions can maintain homeostasis between the two types of metabolism remains largely unknown. Here, we establish a 'falconized' mouse model based on an adaptive EPAS1 genetic variant identified from saker falcons (Falco cherrug) on the Qinghai-Tibet Plateau (QTP). We show that homeostasis between glucose and lipid metabolism in the liver under chronic hypoxia is maintained in male falconized mice. This homeostasis is mediated by genetic factors a

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12552432 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature