Impact of obesity on myocardial function and survival after cardiac arrest and cardiopulmonary resuscitation in a rat model.

ABSTRACT: Obesity is a recognized risk factor for cardiovascular morbidity and mortality, however its impact on survival following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remains controversial. Therefore, the aim of this study was to evaluate the feasibility of a preclinical model of CA/CPR in obese rats as well as 72-hour (h) survival, and investigate the effect of obesity on myocardial dysfunction post-CA/CPR. Rats were subjected to 6 min of untreated ventricular fibrillation and to 6 min of CPR. Hemodynamic parameters were continuously recorded up to 4 h, serial blood samples were collected and echocardiography was performed at 2 and 4 h after resuscitation. Rats were sacrificed 72 and 4 h after resuscitation. After CA, no obese rats survived up to 72 h compared to controls wh

SUBMITTER: Cerrato M 

PROVIDER: S-EPMC12552453 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature