Analytical and clinical comparison of four SLE-associated autoantibodies in different autoimmune diseases.

ABSTRACT: Autoantibodies associated with systemic lupus erythematosus (SLE) are often present in patients with a variety of autoimmune diseases, affecting the diagnosis and differentiation of the diseases. In this study, the positive rates and diagnostic efficiencies of anti-dsDNA, anti-nucleosome, anti-ribosomal P and anti-C1q antibodies were analysed in 216 SLE patients, 323 rheumatoid arthritis (RA) patients, 87 Sjogren's syndrome (SS) patients, 45 patients with other autoimmune diseases (OAD) and 52 healthy controls (HC). In addition to being high in SLE patients, the serum levels of anti-dsDNA and anti-nucleosome antibodies were also significantly higher in SS patients compared with OAD (P = 0.008, < 0.001). The ROC-AUCs for the four SLE-associated autoantibodies in distinguishing SLE patients

SUBMITTER: Yang J 

PROVIDER: S-EPMC12552497 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature