Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice.

ABSTRACT:

Background & aims

Formylated peptide receptors 1 and 2 (Fpr1/2 or FPRs) are G-protein-coupled pattern recognition receptors that bind bacterial formylated peptides. The role of FPRs in enteric nervous system (ENS) development and gastrointestinal (GI) motility is unknown.

Methods

We generated mice with germline, epithelial-, and neural crest-specific deletion of the Fpr1/2 locus and assessed ENS structure and GI motility. We also employed a gestational microbiota suppression model using antibiotic-treated wild-type dams, alongside a transient gestational colonization model in pregnant germ-free mice using auxotrophic Escherichia coli, to determine whether temporary restoration of maternal microbiota-Fpr1/2 signaling can regulate embryonic ENS development. Enteric neuronal de

SUBMITTER: Chandrasekharan B 

PROVIDER: S-EPMC12552559 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature