X-ray-driven nanomotor with enhanced penetration and retention for carbon monoxide-amplified radioimmunotherapy of advanced colorectal cancer.

ABSTRACT: Most advanced colorectal cancer (CRC) with peritoneal metastasis have been managed by radiotherapy and following localized perfusion of therapeutic agents. However, the efficacy of intraperitoneal treatment remains limited by poor drug penetration, inadequate retention within tumor tissues, and a complex tumor microenvironment. Here we report the development of an X-ray-activated nanomotor, GM-R848, comprising an iron carbonyl (FeCO) prodrug framework encapsulating the TLR7 agonist resiquimod (R848), designed for efficient tumor cell elimination and immune activation. Upon X-ray irradiation, rapid decomposition of the FeCO framework generates carbon monoxide (CO) bubbles, propelling enhanced penetration and retention of the nanomotors within colorectal tumor tissues. Following internalizat

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12552560 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature