Radiotherapy as a surgical alternative in ductal carcinoma in situ (DCIS): long-term survival benefits and predictors of invasive progression risk.

ABSTRACT:

Background

Currently, the incidence of ductal carcinoma in situ (DCIS) is gradually increasing. Considering its overall favorable prognosis, some studies have explored exempting patients from surgery for potentially low-risk patients. This retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database investigates whether omitting surgery and administering only local radiotherapy (RT) affects the prognosis of patients.

Methods

A total of 2,363 patients with DCIS who did not receive surgery were identified from the SEER database. Propensity score matching (PSM) and Kaplan-Meier method were applied to analyze the impact of RT alone. Cox regression analyses and competitive risk models were used to examine factors related to the progression of D

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12552565 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature