From lab to pilot: sonochemical coating of PDDA-based polymer dots for scalable, wash-durable antibacterial textiles.

ABSTRACT: Poly(diallyldimethylammonium chloride) (PDDA) is a cationic polymer with strong antibacterial activity, but its coating applications are hindered by limited stability and dose-dependent cytotoxicity. Nanoformulating PDDA into polymer dots (PDDA-based PDs) via hydrothermal synthesis with boric acid offers enhanced biocompatibility, stability, and antimicrobial efficacy. The synthesised PDs demonstrated potent antibacterial activity against Gram-positive (S. aureus) and Gram-negative bacteria (E. coli and P. aeruginosa) with MIC values of 0.056-0.112 mg/mL and superior biofilm inhibition capabilities. Significantly lower antimicrobial resistance development was observed, with only 4-8 fold MIC increase after 30 days compared to 128-2048 fold increase for conventional antibiotics. Sonochemica

SUBMITTER: Rathee G 

PROVIDER: S-EPMC12552576 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature