Tectorigenin induces vasorelaxation in porcine coronary arteries through activation of Kv channels and oestrogen receptor modulation.

ABSTRACT: Ischaemic heart disease remains a leading cause of mortality worldwide, highlighting the need for new agents that protect vascular function. Tectorigenin, a plant-derived isoflavone, is known for its anti-inflammatory and antioxidant properties, but its direct effects on vascular tone have not been clearly explored. This study investigated the vasorelaxant actions of tectorigenin in endothelium-denuded porcine coronary arteries and examined the mechanisms involved. Using isolated artery rings pre-contracted with a thromboxane A₂ analogue, we found that tectorigenin induced concentration-dependent relaxation with an EC₅₀ of approximately 11 µM. Pharmacological inhibition experiments revealed that relaxation at 10-30 µM was significantly reduced by oestrogen receptor antagonists and by 4-ami

SUBMITTER: Chen TY 

PROVIDER: S-EPMC12552588 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature