Longitudinal parametric response mapping on CT in assessing functional small airway disease and emphysema in COPD.

ABSTRACT: Parametric response mapping (PRM) on computed tomography (CT) is an imaging technique for assessing small airway disease (SAD) and emphysema in chronic obstructive pulmonary disease (COPD). This study was aimed to examine the relationship between individual spirometry components decline and PRM-CT-derived data changes over a 6-year observation period in mild and moderate COPD patients using a COPD cohort chronically exposed to dust. This study utilized longitudinal data of the COPD in Dusty Areas (CODA) cohort from 2012 to 2014. COPD was confirmed by a post-bronchodilator forced expiratory volume in one second (FEV₁) over forced vital capacity (FVC) value < 0.70. Among the 427 included patients, 106 with 6-year follow-up PRM CT data and having mild (FEV₁% of the predi

SUBMITTER: Kim T 

PROVIDER: S-EPMC12552647 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature