Increased cancer risk in patients with IgG4-related disease in a nationwide South Korean cohort, 2012-2021.

ABSTRACT: Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition that has been suggested to increase cancer risk, but the incidence and types of associated malignancies remain unclear. This study aimed to evaluate the cancer risk in patients with IgG4-RD using a nationwide population-based cohort. We identified 2,150 patients newly diagnosed with IgG4-RD between January 2012 and December 2020 from the Korean National Health Insurance Service database. Patients were followed until the occurrence of cancer, death, or December 31, 2021. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated to compare cancer incidence in IgG4-RD patients with that in the general population. Subgroup analyses were conducted based on sex, age at diagnosis, follow-

SUBMITTER: So H 

PROVIDER: S-EPMC12552652 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature