The gut feeling in motion sickness.

ABSTRACT: Motion sickness is a nearly universal response to the unnatural motions that are experienced when traveling by means other than the body's own faculties; in artificial realities; and in micro- and partial gravity environments. Despite being a known malady since ancient times, its underlying mechanisms, as well as the marked interpersonal variability in susceptibility, remain incompletely understood. While efferent brain-to-body signaling pathways involved in motion sickness have been previously described, recent findings on the functional role of the gut's (neuro)epithelial cells and microbiome point to a more intricate biological control system than previously appreciated. We examine (afferent) anatomical, hormonal, immune, and extracellular brain-body pathways, and their potential role i

SUBMITTER: Talsma TMW 

PROVIDER: S-EPMC12552690 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature