Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study.

ABSTRACT: Chronic pain (CP) is closely related with major depressive disorder (MDD) and anxiety disorders (ANX), with high comorbidity and shared risk factors. Prior studies have demonstrated common neural correlates across the three disorders, but their neuroanatomic basis is not fully clear. Hence, the preregistered meta-analysis (CRD42019119709) intended to explore common alterations in cortical thickness among CP, MDD, and ANX, a widely used parameter for quantitatively assessing various cerebral conditions with high sensitivity to pathology in neuropsychology. A total of 68 studies comprising 3072 patients and 3427 healthy controls were finally included. Across the disorders, four common clusters with a significant reduction in cortical thickness were identified, including right insula, left an

SUBMITTER: Yu W 

PROVIDER: S-EPMC12552705 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature