Cell type- and species-specific regulation of hepatic lncRNAs by TCDD-activated aryl hydrocarbon receptor.

ABSTRACT: 2,3,7,8-Tetrachlorodibenzio-p-dioxin (TCDD) is a persistent environmental contaminant known for aryl hydrocarbon receptor (AHR)-mediated liver effects, including metabolic dysfunction-associated steatotic liver disease (MASLD)-like pathologies such as steatosis, inflammation, and fibrosis. Although previous studies have focused on AHR-mediated regulation of protein-coding genes, recent attention has turned to long non-coding RNAs (lncRNAs) because of their potential roles in the progression of steatotic liver disease (SLD). Using bulk and single-nuclei (sn)RNAseq datasets, we compared the dose-dependent AHR-mediated induction of lncRNA and mRNA expression by TCDD in the mouse and rat liver. This study also investigated cell-specific lncRNA-gene regulation within the murine liver to identif

SUBMITTER: Post GA 

PROVIDER: S-EPMC12552753 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature