Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk.

ABSTRACT:

Background and objectives

Glymphatic dysfunction occurs in Parkinson's disease (PD), but its status in prodromal PD (pPD) is unclear. Using the diffusion tensor imaging along perivascular spaces (DTI-ALPS) index as an indirect proxy, this study aims to evaluate glymphatic-related changes in a pPD cohort and to explore their relationship with symptoms, gray matter volume, and risk of phenoconversion.

Methods

We analyzed data from the Parkinson's Progression Marker Initiative, including 51 healthy controls (HC), 83 individuals with pPD, and 202 with de novo PD (dnPD). The pPD cohort underwent ≥ 4-year follow-up. Cross-sectional analyses compared the DTI-ALPS index across three groups and examined associations between the DTI-ALPS index and clinical features/gray matter volume

SUBMITTER: Chen A 

PROVIDER: S-EPMC12552785 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature