Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density.

ABSTRACT:

Objective

While the phenotypic associations of menstrual traits, such as age at menarche (AAM) and age at natural menopause (ANM), with bone mineral density (BMD) have been well observed, the understanding of their shared genetic mechanisms is lacking. We aimed to systematically explore the underlying genetic basis connecting AAM and ANM with BMD.

Methods

We performed a large-scale genome-wide cross-trait analysis by leveraging summary statistics from the hitherto largest genome-wide association studies conducted among the European population for AAM (n = 556,124), ANM (n = 201,323), and heel estimated BMD (eBMD, n = 426,824), a robust validated predictor of osteoporosis risk.

Results

We identified significant genetic correlations for eBMD with both AAM (r g = -0.082,

SUBMITTER: Lei B 

PROVIDER: S-EPMC12552850 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature