Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) generally exhibits favorable prognosis; however, a subset of patients remains at risk for recurrence. Serine protease 2 (PRSS2) was an oncogenic factor in several solid tumors, yet its expression profile and functional role in PTC remain poorly defined. This study aimed to investigate the expression level of PRSS2 in PTC and its prognostic significance, as well as explore its potential involvement in immune regulatory mechanisms.

Methods

PTC specimens from thyroidectomy patients were analyzed by transcriptomic analysis, quantitative real-time PCR, and immunohistochemistry. Differential gene expression and survival analyses were performed by integrating data from TCGA and GEO databases. Pearson correlation analysis was utilized to

SUBMITTER: Lin W 

PROVIDER: S-EPMC12552859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature