Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time.

Methods

We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal autosomal dominant AD (ADAD) sample (N = 379) with amyloid positron emission tomography. We compared (1) predicted age at A+ to imputed age, (2) estimated age at A+ to estimated age at symptom onset, and (3) variance in cognitive performance explained.

Results

Mean error between imputed and SILA-estimated age at A+ (N = 26) was 1.15 years. Age at A+ explained 39% of estimated years to symptom onset (EYO) variance. Time from A+ explained 19% of cognitive composite variance and 14% of Clinical Dementia Rating Sum of Boxes CDR-SB variance;

SUBMITTER: Wisch JK 

PROVIDER: S-EPMC12552894 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature