Reviewing the possible connection between cerebral amyloid angiopathy and blood-brain barrier integrity in Down syndrome.

ABSTRACT: Individuals with Down syndrome (DS) have a higher risk of developing cerebral amyloid angiopathy (CAA), primarily because of the excessive production of amyloid beta (Aβ). However, the consequences of CAA on blood-brain barrier (BBB) integrity and the neurovascular unit (NVU) are still not well understood. Systematic search was conducted on PubMed using 12 targeted keywords related to CAA, BBB, and the NVU in combination with DS. Additional sources were identified and the research gap validated using Consensus and ChatGPT-assisted literature screening. Individuals with DS are vulnerable to cerebrovascular conditions across their lifespan. Despite pronounced Aβ pathology, CAA appears less frequent than in cases with microduplication of the APP locus, suggesting distinct vascular dynamics po

SUBMITTER: Valay L 

PROVIDER: S-EPMC12552899 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature