Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas.

ABSTRACT:

Abstract

Mature T-cell leukemias and lymphomas (mTCL) comprise a clinically and genetically heterogeneous group of lymphoid malignancies. Most subtypes of peripheral T-cell lymphomas and leukemic T-cell malignancies show an aggressive clinical course and poor prognosis. Thus, these diseases urgently require novel therapeutic strategies. Taking advantage of recent progress deciphering the genetic basis of mTCL, we generated a comprehensive database of genetic alterations from 1825 patients with mTCL and utilized bioinformatic methodology developed to support treatment decisions in molecular tumor boards to identify novel potential therapeutics. Based on the results of this approach, we performed a systematic in vitro drug screen in molecularly characterized cell lines of mTCL to ass

SUBMITTER: Schmidt N 

PROVIDER: S-EPMC12552946 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature