Identifying therapeutic targets for allergic asthma through atopic dermatitis-associated genetic mechanisms.

ABSTRACT:

Background

Allergic asthma (AA) is a chronic inflammatory disease with limited effective treatments, often co-occurring with atopic dermatitis (AD). Epidemiologic studies have shown a strong association between AD and AA, but their causal relationship remains unclear.

Objectives

This study aimed to identify novel therapeutic targets and candidate drugs for AA.

Methods

We performed Mendelian (MR) analysis to evaluate the causal relationship between AD and AA. To identify potential therapeutic targets, we integrated drug-target MR, colocalization, functional enrichment, protein-protein interaction, and gene expression analyses. Drug candidates were prioritized using the Drug-Gene Interaction Database (DGIdb; dgidb.org) and the Comparative Toxicogenomics Database (CTD; c

SUBMITTER: Pu Y 

PROVIDER: S-EPMC12552950 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature