Therapeutic Shifts and Scientific Influence in Treatment-Resistant Depression Research: A Data-Driven Perspective.

ABSTRACT:

Background

Treatment-resistant depression (TRD) remains a major psychiatric challenge, with therapeutic paradigms evolving over the last 50 years. However, research on TRD is fragmented across molecular mechanisms, clinical interventions, and epidemiological trends, highlighting the need for a comprehensive synthesis to guide future studies and enhance clinical outcomes.

Methods

We conducted a large-scale bibliometric analysis of 16,198 TRD-related publications from PubMed, Web of Science, and Scopus (1974-2025). Using CiteSpace, VOSviewer, and Bibliometrix, we quantified publication trends, collaborative networks, and thematic shifts. Special attention was paid to influential researchers and institutions, as well as examining the shifting research focus from traditional inv

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12552951 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature