Perinatal antibiotic exposure and risk of childhood infections: a retrospective cohort study.

ABSTRACT:

Background

Epidemiological studies report associations between antibiotics given during pregnancy, childbirth, and infancy and subsequent risk for childhood infections. The specific role of intrapartum and neonatal antibiotic exposures is not well-described.

Methods

Retrospective cohort study of healthy term infants through 6 years of age. The primary exposure was perinatal antibiotics, defined as intravenous intrapartum antibiotic administration during the admission for childbirth or administered to the infant ≤3 days after birth. The primary outcome was infection-related inpatient encounters. Adjusted multivariable-adjusted Cox proportional hazards and marginal means/rates models were used to investigate the association between exposure and outcome. A secondary analysis ex

SUBMITTER: Coggins SA 

PROVIDER: S-EPMC12553004 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature